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Physicians need to focus on with patients the contraindication of VIAGRA with utilization of guanylate cyclase stimulators including riociguat [see CONTRAINDICATIONS].i.d.) resulted in the sixty three% lessen of sildenafil AUC in addition to a 55% reduce in sildenafil Cmax . Concomitant administration of robust CYP3A4 inducers, such as rifampin, is